Science

Innovative Solutions Demand Better Science

Innovative
Solutions Demand
Better Science

3D rendering of a chromatin molecule.

Differences

What We See That Others Miss

What We See
That Others Miss

Epigenetic proteins are not static structures. Their functional conformations emerge from interactions with chromatin, histone modifications, and other proteins in the complex.

3D ribbon diagram of a protein structure with red, green, and blue domains on a transparent background.

Conventional Approaches

The Limits of
Static Models

Conventional drug discovery studies isolated proteins. Static structures and PDB-trained AI models cannot capture the dynamic conformations that emerge within chromatin.

3D rendering of three nucleosomes with blue DNA wrapped around colorful histone proteins on a transparent background.

TippingPoint's Science

Reconstituting
Disease States

We recreate disease-specific chromatin states, capturing conformations that only emerge within functional biological systems.

Solution

Beyond the Static Structure

Our platform reconstitutes three-dimensional chromatin states in vitro, capturing dynamic, multi-component conformations that static structures and PDB-trained AI models can't resolve.

The biological context driving disease.
The biological context driving disease.

Platform Output

The Data Behind the Discovery

01

Experimentally Generated

Generated systematically against validated disease targets using reproducible experimental protocols.

02

Beyond Our Own Pipeline

This unique class of experimental data supports new discoveries across drug discovery and computational biology.

03

Designed for Collaboration

We're collaborating with organizations that share our vision for the future of drug discovery.

01

Experimentally Generated

Generated systematically against validated disease targets using reproducible experimental protocols.

02

Beyond Our Own Pipeline

This unique class of experimental data supports new discoveries across drug discovery and computational biology.

03

Designed for Collaboration

We're collaborating with organizations that share our vision for the future of drug discovery.

01

Experimentally Generated

Generated systematically against validated disease targets using reproducible experimental protocols.

02

Beyond Our Own Pipeline

This unique class of experimental data supports new discoveries across drug discovery and computational biology.

03

Designed for Collaboration

We're collaborating with organizations that share our vision for the future of drug discovery.

Let's Shape the Next Generation
of Drug Discovery

Whether you're exploring a scientific collaboration, strategic partnership, or simply want to learn more about our platform, we'd love to start the conversation.