TIPPINGPOINT

BIOSCIENCES

TIPPINGPOINT

BIOSCIENCES

Undruggable Was Never the Real Barrier 

A New Axis of Druggability: disease-specific conformations

Conventional drug discovery screens proteins in isolation. TippingPoint rebuilds the chromatin systems they actually operate in. That's why we find what others miss.

The Problem

Drug Discovery has a Blind Spot

Most approaches study proteins alone. But in living cells, proteins function within chromatin assemblies that shape their structure and behavior. When that context is missing, critical disease biology stays hidden.

The Problem

Drug Discovery has a Blind Spot

Most approaches study proteins alone. But in living cells, proteins function within chromatin assemblies that shape their structure and behavior. When that context is missing, critical disease biology stays hidden.

Chromatin through a micorscope

What We See That Others Miss

Woman looking through a microscope
Chromatin through a micorscope

What We See
That Others Miss

Woman looking through a microscope

Our Approach

We Stopped Screening Proteins and Started Rebuilding Biology

Epigenetic proteins don't act alone. We reconstitute full chromatin assemblies in vitro, capturing disease-specific conformations that static structural biology and AI structure predictors can't see, because those methods were never built to see them.

The result: we can target chromatin dysfunction at its source, opening up disease-relevant interfaces long considered undruggable.

Unlocking New Therapeutic Opportunities

Unlocking NewTherapeutic Opportunities

Unlocking New Therapeutic Opportunities

Reveal
Hidden Biology

Reveal Hidden Biology

Invisible to protein-only platforms.

Expand the
Target Space

Expand the Target Space

Beyond static protein structure.

Accelerate
Discovery

Accelerate Discovery

With a reproducible, scalable screening system.

Backed by Those Who Believe

An IndieBio company

An IndieBio company

We Are Part of the brightedge entrepeneurs (BEE) program

We Are Part of the brightedge entrepeneurs (BEE) program

Investors

Investors

  • Logo of The Sontag Foundation
    Logo of Freeflow
    Logo of Sazze Partners
    Logo of Storyhouse Ventures
    Logo of SOSV
    Logo of Xeia
    Logo of mission biocapital
    Logo of Pediatric Brain Tumor Foundation
    Logo of Yuvaan Tiwari Foundation
    Logo of Lexi Ventures
    Logo of Conscience
    Logo of American Cancer Society
    Logo of West Coast Angel Network
    Logo of Asymmetry Ventures

Platinum / Golden Ticket Sponsors

Platinum / Golden Ticket Sponsors

  • Logo of Ono Pharma
    Logo of Astellas
    Logo of AbbVie
    Logo of MBC Biolabs
    Logo of mission biocapital

News & Press Releases

Latest from TippingPoint

Latest from TippingPoint

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Let's Shape the Next Generation
of Drug Discovery

Whether you're exploring a scientific collaboration, strategic partnership, or simply want to learn more about our platform, we'd love to start the conversation.